反应详情

A flask was charged with tert-butyl 4-(3-(4-nitro-3-(trifluoromethyl)phenoxy)propyl)piperazine-1-carboxylate (0.78 g, 1.8 mmol), ammonium formate (0.45 g, 7.2 mmol), and iron powder (0.40 g, 7.2 mmol). Toluene (15 mL) and water (15 mL) were added to the flask and the mixture was heated to reflux for 2 hours, after which time, the hot mixture was filtered through a plug of Celite. The solvent was removed on a rotary evaporator under reduced pressure to yield tert-butyl 4-(3-(4-amino-3-(trifluoromethyl)phenoxy) propyl)piperazine-1-carboxylate. The material was used without further purification. MS (EI): 404 (MH+).

1. temperaturethe mixture was heated
2. temperatureto reflux for 2 hours
3. filtrationafter which time, the hot mixture was filtered through a plug of Celite
4. customThe solvent was removed on a rotary evaporator under reduced pressure