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HRID415871

反应详情

EQUATION

反应方程式

HRID 415871 的结构方程式

REACTANTS

反应物

4
结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1
HCID199401

Phosphinic azide, diphenyl-

C12H10N3OP

结构：CC(C)OC(=O)/N=N/C(=O)OC(C)C
HCID5363146

Diisopropyl azodicarboxylate

C8H14N2O4

结构：COC(=O)[C@H]1NCC[C@H]1O
HCID45082777

Methyl (3R)-3-hydroxy-L-prolinate

C6H11NO3

PRODUCTS

生成物

1
结构：COC(=O)[C@H]1NCCC1N=[N+]=[N-]
HCID59162825

未命名化合物

PROCEDURE

实验过程

Reaction of cis-3-hydroxyproline methyl ester with DIAD, triphenylphosphine and diphenylphosphoryl azide provides the desired 3-azido proline methyl ester. Transformation is typically carried out at low temperatures, e.g., 0° C., and after the addition, the reaction is allowed to warm to ambient temperature, e.g., about 25° C.