Potassium Carbonate → HCID 25061283, compound

HRID 416097Notes

Reaction equation

HRID 416097 reaction equation
[OH:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH2:9][CH2:10][C:11]([C:13]2[S:14][C:15]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)=[CH:16][CH:17]=2)=[O:12])=[CH:4][C:3]=1[CH3:28].Br[C:30]([CH3:39])([CH3:38])[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32].C(=O)([O-])[O-].[K+].[K+]>>[CH3:8][C:7]1[CH:6]=[C:5]([CH2:9][CH2:10][C:11](=[O:12])[C:13]2[S:14][C:15]([C:18]3[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=3)=[CH:16][CH:17]=2)[CH:4]=[C:3]([CH3:28])[C:2]=1[O:1][C:30]([CH3:39])([CH3:38])[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 59180337HCID 59180337, compound

Product 1

HCID 25061283HCID 25061283, compound

Procedure

Tert-butyl 2-(2,6-dimethyl-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)-2-methylpropanoate is prepared from 3-(4-hydroxy-3,5-dimethylphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propan-1-one according to general procedure D, using 15 equivalents of tert-butyl bromoisobutyrate and 15 equivalents of potassium carbonate added in portions of 3 equivalents in the course of the reaction.

Workup

  1. additionadded in portions of 3 equivalents in the course of the reaction

Sources & evidence

ORD record
ord-72aa4f8f5f014ee1823cf2c5916c20bd
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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