Trifluoroacetic acid → HCID 59180328, compound

HRID 416105Notes

Reaction equation

[Cl:1][C:2]1[C:18]([Cl:19])=[C:17]([CH2:20][CH2:21][C:22](=[O:34])[C:23]2[S:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH:16]=[CH:15][C:3]=1[O:4][C:5]([CH3:14])([CH3:13])[C:6]([O:8]C(C)(C)C)=[O:7].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[C:18]([Cl:19])=[C:17]([CH2:20][CH2:21][C:22](=[O:34])[C:23]2[S:24][C:25]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[CH:26][CH:27]=2)[CH:16]=[CH:15][C:3]=1[O:4][C:5]([CH3:14])([CH3:13])[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59180331HCID 59180331, compound

Product 1

HCID 59180328HCID 59180328, compound

Procedure

2-(2,3-Dichloro-4-(3-oxo-3-(5-phenylthien-2-yl)propyl)phenoxy)-2-methylpropanoic acid is prepared from tert-butyl 2-(2,3-dichloro-4-(3-oxo-3-(5-phenylthien-2-yl)propyl)phenoxy)-2-methylpropanoate according to general procedure E using 12 equivalents of trifluoroacetic acid. After stirring for 12 hours at room temperature, the reaction mixture is washed with water and then the dichloromethane is removed by evaporation under reduced pressure.

Workup

washthe reaction mixture is washed with water
customthe dichloromethane is removed by evaporation under reduced pressure

Sources & evidence

ORD record: ord-935d60c174bd4033b96a0bdd9ba7f013
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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