反应详情

温度

90 °C

To a solution of 4-methoxyphenylboronic acid (3.0 g, 19.7 mmol) and 2,4-dichloropyrimidine (5.9 g, 39.0 mmol) in dry acetonitrile (120 mL) was added a 0.4 M solution of Na2CO3 (120 mL) followed by Pd(PPh3)4 (400 mg, 0.35 mmol). The suspension was degassed and heated at 90° C. for 16 h, cooled down and concentrated to produce a precipitate which was collected by filtration, washed with water, dried and purified by flash chromatography on silica gel (EtOAc/CH2Cl2: 5/95) to afford the title compound 17 (4.25 g, 19.3 mmol, 97% yield).

1. customThe suspension was degassed
2. temperaturecooled down
3. concentrationconcentrated
4. customto produce a precipitate which
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried
8. custompurified by flash chromatography on silica gel (EtOAc/CH2Cl2: 5/95)