反应详情

温度

40 °C

To a solution of 20 (1.9 g, 4.2 mmol) in a mixture of THF (8 mL), MeOH (8 mL) and water (4 mL) was added NaOH (373 mg, 9.3 mmol). The mixture was heated at 40° C. for 16 h, then acidified to pH 6 by adding 1N HCl, concentrated, and dried under high vacuum to afford the title compound 21, which was used without further purification.

1. concentrationconcentrated
2. customdried under high vacuum