Hydrazine → HCID 66625026, compound

HRID 416517Notes

Reaction equation

HRID 416517 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH2:27][C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[S:11]([CH2:14][CH2:15][N:16]2C(=O)C3C(=CC=CC=3)C2=O)(=[O:13])=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].NN>C1COCC1>[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH2:27][C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[S:11]([CH2:14][CH2:15][NH2:16])(=[O:12])=[O:13])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 66625058HCID 66625058, compound

Product 1

HCID 66625026HCID 66625026, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Amino-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-thiazol-2-ylmethyl-amide was prepared by an analogous procedure as described for example 1 ii) starting from 178 mg (0.37 mmol) 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid (1-isopropyl-piperidin-4-yl)-thiazol-2-ylmethyl-amide and 0.75 ml (2 equiv.) of a 1M hydrazine-solution in THF. The product was obtained as brown oil. Yield: 140 mg MS (ES+): m/e=347.

Workup

  1. customThe product was obtained as brown oil

Sources & evidence

ORD record
ord-4fed218800c6411c92d419aee7ab84b8
Source dataset
uspto-grants-2012_01
Patent number
US08088925B2

Reaction notes

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