Trifluoroacetic acid → HCID 86660476, compound

HRID 41725Notes

Reaction equation

C(O)(C(F)(F)F)=O.[C:8]12([C:18]3[CH:19]=[C:20]([C:44]4[CH:49]=[CH:48][C:47](/[CH:50]=[CH:51]/[C:52]([O:54]C(C)(C)C)=[O:53])=[CH:46][CH:45]=4)[CH:21]=[CH:22][C:23]=3[O:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH:33]=[CH:34][CH2:35][CH:36]=[CH:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2>C(Cl)Cl>[C:8]12([C:18]3[CH:19]=[C:20]([C:44]4[CH:45]=[CH:46][C:47]([CH:50]=[CH:51][C:52]([OH:54])=[O:53])=[CH:48][CH:49]=4)[CH:21]=[CH:22][C:23]=3[O:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]/[CH:33]=[CH:34]/[CH2:35][CH:36]=[CH:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:9][CH:10]3[CH2:11][CH:12]([CH2:13][CH:14]([CH2:16]3)[CH2:15]1)[CH2:17]2

Participants

Conditions

Temperature: 0 °C

Procedure

TFA (1.6 ml) was dropped into an ice-cooled solution of octadeca-9,12-dienoic acid (E)-3-adamantan-1-yl-4′-(2-tert-butoxycarbonylvinyl)biphenyl-4-yl ester (110 mg, 0.159 mmol) in DCM (1.6 ml) and the resulting solution was stirred for 30 min at 0° C. The solvent was removed under reduced pressure to obtain the title compound as a white solid (100 mg, 99%).

Workup

customThe solvent was removed under reduced pressure

Sources & evidence

ORD record: ord-45c5b184600743c9a414bb750fa959a8
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530517B2

Reaction notes

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