反应详情

Synthesized as described for the preparation of compound BC1. Quantities: 25 (0.22 g, 0.37 mmol), 22 (0.20 g, 0.37 mmol), DMAP (0.045 g, 0.37 mmol), DCC (0.15 g, 0.73 mmol). Yield 0.25 g (61%). EA: Found: C, 64.49; H, 6.81. C61H73BrO11S2 requires C, 65.05; H, 6.53%. 1H NMR: δH (CDCl3; 300 MHz): 1.22-1.62 (35 H, m, CH2/O—CH2—CH3), 1.71 (2 H, m, S—CH2—CH2), 1.87 (6 H, m, O—CH2—CH2/Br—CH2—CH2), 3.13 (2 H, t, 3J=7.4 Hz, SCH2), 3.42 (2 H, t, 3J=6.8 Hz, CH2Br), 4.07 (4 H, t, 3J=6.5 Hz, OCH2), 4.66 (2 H, q, 3J=7.1 Hz, O—CH2—CH3), 7.01 (2 H, d, 3J=8.7 Hz, Ar—H), 7.21 (3 H, m, Ar—H), 7.40 (4 H, d, 3J=8.5 Hz, Ar—H), 7.51 (1 H, t, 3J=8.1 Hz, Ar—H), 8.17 (4 H, d, 3J=8.7 Hz, Ar—H), 8.30 (4 H, d, 3J=8.5 Hz, Ar—H). 13C NMR: δC (CDCl3; 75 MHz): 13.8, 26.0, 28.2, 28.3, 28.8, 28.9, 29.0, 29.3, 29.35, 29.4, 29.5, 31.7, 32.8, 34.0, 35.9, 53.8, 68.4, 69.5, 69.7, 114.4, 115.8, 119.3, 120.9, 122.1, 126.6, 129.9, 131.9, 132.4, 151.4, 155.5, 163.8, 164.1, 164.3, 210.8. m/z (MALDI) 1147.56 (100%) and 1149.59 (97%) [M+Na]+, C61H73BrNaO11S2 requires 1147.37 (100.0%) and 1149.37 (97%).

1. customSynthesized
2. customas described for the preparation of compound BC1