反应详情

Methyl isonipecotinate (1.0 g, 6.98 mmol) in tetrahydrofuran was mixed with thiocarbonyldiimidazole (1.24 g, 6.98 mmol) at room temperature and then stirred at room temperature for 1.5 hours and stirred with hydrazine monohydrate (700 mg, 14.0 mmol) for another 4 hours. The reaction solution was mixed with saturated aqueous sodium chloride and extracted with ethyl acetate and chloroform. The extract was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated to give the crude preparation of the desired product (114% yield).

1. extractionextracted with ethyl acetate and chloroform
2. dry with materialThe extract was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. concentrationthe filtrate was concentrated
5. customto give the crude