HRID418346

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID57634222

N-[4-[(Dimethylamino)methyl]-2-thiazolyl]acetamide

C8H13N3OS

PRODUCTS

生成物

HCID86639092

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度: 50 °C

PROCEDURE

实验过程

Dissolved N-(4-dimethylaminomethyl-thiazol-2-yl)-acetamide (274 mg, 1.38 mmol) in 5 mL of EtOH. Added 2 mL of 4 M HCl in dioxane and heated at 50° C. for 16 h. LC-MS analysis indicated complete acetyl removal. Concentrated to give 274 mg of 4-dimethylaminomethyl-thiazol-2-ylamine dihydrochloride.

WORKUP

后处理

customacetyl removal
concentrationConcentrated