Hydrochloric Acid → HCID 86639092, compound

HRID 418346Notes

Reaction equation

HRID 418346 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[N:6]=[C:7]([NH:10]C(=O)C)[S:8][CH:9]=1)[CH3:3].[ClH:14]>CCO.O1CCOCC1>[ClH:14].[ClH:14].[CH3:1][N:2]([CH2:4][C:5]1[N:6]=[C:7]([NH2:10])[S:8][CH:9]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57634222N-[4-[(Dimethylamino)methyl]-2-thiazolyl]acetamide

Product 1

HCID 86639092HCID 86639092, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

Dissolved N-(4-dimethylaminomethyl-thiazol-2-yl)-acetamide (274 mg, 1.38 mmol) in 5 mL of EtOH. Added 2 mL of 4 M HCl in dioxane and heated at 50° C. for 16 h. LC-MS analysis indicated complete acetyl removal. Concentrated to give 274 mg of 4-dimethylaminomethyl-thiazol-2-ylamine dihydrochloride.

Workup

  1. customacetyl removal
  2. concentrationConcentrated

Sources & evidence

ORD record
ord-18d1573500e74f709e0268243ee45b48
Source dataset
uspto-grants-2012_01
Patent number
US08093266B2

Reaction notes

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