反应详情

To a solution of 1-pyrazin-2-yl-ethanone (2.0 g, 15.85 mmol) and ammonium acetate (19.337 g, 158.5 mmol) in methanol (50 mL) was added sodium cyanoborohydride (0.7 g, 11.1 mmol) in one portion. The reaction mixture was stirred overnight at room temperature. After removal of methanol, water (20 mL) was added to the residue and the resulting solution was basified by addition of sodium hydroxide to pH=13. The aqueous solution was extracted with dicholromethane and the combined organic phase was dried over sodium sulfate. Removal of the solvent under reduced pressure afforded 14.62 g of 1-pyrazin-2-yl-ethylamine, yield: 75%. MS (M+H)=124.

1. customAfter removal of methanol, water (20 mL)
2. additionwas added to the residue
3. additionthe resulting solution was basified by addition of sodium hydroxide to pH=13
4. extractionThe aqueous solution was extracted with dicholromethane
5. dry with materialthe combined organic phase was dried over sodium sulfate
6. customRemoval of the solvent under reduced pressure