Sodium Hydroxide → HCID 10384843, compound

HRID 418447Notes

Reaction equation

HRID 418447 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH3:23])[CH:21]=2)[N:16]([CH2:24][C:25]([O:27]CC)=[O:26])[C:15]=1[CH3:30])([O-:3])=[O:2].[OH-].[Na+]>C1COCC1>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH3:23])[CH:21]=2)[N:16]([CH2:24][C:25]([OH:27])=[O:26])[C:15]=1[CH3:30])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86600927HCID 86600927, compound

Product 1

HCID 10384843HCID 10384843, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 40 step b) (0.50 g) was suspended in THF (10 ml) and to it added 1M sodium hydroxide (1.24 ml) for the mixture to be stirred overnight at room temperature to complete the reaction. The solution was evaporated to dryness and purified by Reverse Phase Preparative HPLC to give the title compound as a yellow solid (0.31 g).

Workup

  1. customthe reaction
  2. customThe solution was evaporated to dryness
  3. custompurified by Reverse Phase Preparative HPLC

Sources & evidence

ORD record
ord-6525eb7ff0b44af5a3492f62425605de
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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