反应详情

5.0 g (30.5 mmol) of phenylpyruvic acid and 12.1 g (91.4 mmol) of oxaloacetic acid are added to 25 ml of water preliminarily dissolving 13.8 g of potassium hydroxide (purity of 85%) therein, for reaction at ambient temperature for 72 hours. Using the conc. hydrochloric acid, the reaction solution is adjusted to pH 2.2, for extraction into ethyl acetate. The organic layer is rinsed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to obtain the residue. The residue is recrystallized in ethyl acetate and toluene to obtain PHOG of 2.8 g (11.3 mmoL) in crystal.

1. customfor reaction at ambient temperature for 72 hours
2. extractionthe reaction solution is adjusted to pH 2.2, for extraction into ethyl acetate
3. washThe organic layer is rinsed with saturated aqueous sodium chloride
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customto obtain the residue
7. customThe residue is recrystallized in ethyl acetate
8. customtoluene to obtain PHOG of 2.8 g (11.3 mmoL) in crystal