Dodecylamine → HCID 16041062, compound

HRID 418602Notes

Reaction equation

HRID 418602 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:24][C:25](=[O:36])[CH2:26][C:27]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)=[O:28])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[CH:15]=[C:16](C3N(C)C=CN=3)[S:17][C:10]=12.FC1C=C(N)C=CC=1OC1C=CN=C2C=C([C:54]3[N:55]([CH3:59])[CH:56]=[CH:57][N:58]=3)SC=12.CCCCCCCCCCCCN>>[F:1][C:2]1[CH:3]=[C:4]([NH:24][C:25](=[O:36])[CH2:26][C:27]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)=[O:28])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[CH:15]=[C:16]([C:56]3[N:55]([CH3:59])[CH:54]=[N:58][CH:57]=3)[S:17][C:10]=12

Participants

4

Reactant 3

HCID 13583DodecylamineHCID 58790352HCID 58790352, compoundHCID 594244803-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

Product 1

HCID 16041062HCID 16041062, compoundYield 33%

Procedure

Following the procedure described above for the compound 40 (example 17, step 2, scheme 14) but substituting the amine 9 for the amine 12, title compound 41 was obtained in 33% yield (scheme 14) 1H NMR (DMSO-d6) δ (ppm): 10.58 (s, 1H), 10.44 (s, 1H), 8.74 (d, 1H), 8.49 (d, 1H), 8.27 (dd, 1H), 8.05 (m, 1H), 7.86 (m, 2H), 7.77 (s, 1H), 7.48 (t, 1H), 7.42 (m, 2H), 7.35 (q, 1H), 6.63 (d, 1H), 3.88 (s, 3H), 3.54 (s, 2H). MS (m/z): 502.7 (M+H).

Sources & evidence

ORD record
ord-054cd4da33c449a99a4cbbdec6c652a6
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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