Sodium Bicarbonate → 2,6-Dibromo-4-methylbenzaldehyde [4-(methyloxy)phenyl]hydrazone

HRID 418774Notes

Reaction equation

HRID 418774 reaction equation
C(=O)(O)[O-].[Na+].[Br:6][C:7]1[CH:14]=[C:13]([CH3:15])[CH:12]=[C:11]([Br:16])[C:8]=1[CH:9]=O.Cl.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][NH2:27])=[CH:22][CH:21]=1>CO>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][N:27]=[CH:9][C:8]2[C:7]([Br:6])=[CH:14][C:13]([CH3:15])=[CH:12][C:11]=2[Br:16])=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 27239044-Methoxyphenylhydrazine hydrochlorideHCID 129827482,6-Dibromo-4-methylbenzaldehyde

Product 1

HCID 666484422,6-Dibromo-4-methylbenzaldehyde [4-(methyloxy)phenyl]hydrazone

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium bicarbonate (0.84 g, 10 mmol) was added to a solution of 2,6-dibromo-4-methylbenzaldehyde (2.62 g, 9.43 mmol) and [4-(methyloxy)phenyl]hydrazine hydrochloride (1.65 g, 9.45 mmol) in methanol (60 mL) and the mixture heated under reflux for 15 min. The mixture was then cooled and evaporated to give the crude title compound which was used without purification.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 15 min
  3. temperatureThe mixture was then cooled
  4. customevaporated

Sources & evidence

ORD record
ord-33c0687de26447fdb234cbc85bd00397
Source dataset
uspto-grants-2012_01
Patent number
US08093281B2

Reaction notes

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