Diethyl Ether → HCID 66652109, compound

HRID 418933Notes

Reaction equation

HRID 418933 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:25](Cl)=[O:26])[C:6]2[CH2:7][CH:8]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[CH:9]3[CH:14]([C:15]=2[CH:16]=1)[CH2:13][CH2:12][CH2:11][CH2:10]3.[NH4+:28].[OH-].C(OCC)C>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:25]([NH2:28])=[O:26])[C:6]2[CH2:7][CH:8]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[CH:9]3[CH:14]([C:15]=2[CH:16]=1)[CH2:13][CH2:12][CH2:11][CH2:10]3

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 14923Ammonium HydroxideHCID 72309427HCID 72309427, compound

Product 1

HCID 66652109HCID 66652109, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Combine 3-Methoxy-9-(4-methoxy-phenyl)-4b,5,6,7,8,8a,9,10-octahydro-phenanthrene-1-carbonyl chloride (0.08 g, 0.18 mmol), NH4OH (2 ml), and diethyl ether (1 ml) at 0-5° C. and stir as such 2 hours. Dilute with ethyl acetate and wash with water. Dry over anhydrous sodium sulfate, and remove solvent in vacuo at 40° C. to yield preparation 121 (0.069 g, 100%). MS m/z 366 (M+1).

Workup

  1. washwash with water
  2. dry with materialDry over anhydrous sodium sulfate
  3. customremove solvent in vacuo at 40° C.
  4. customto yield

Sources & evidence

ORD record
ord-fb29f93b87a84ce88b54d01cb409ba7c
Source dataset
uspto-grants-2012_01
Patent number
US08093302B2

Reaction notes

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