Hydrochloric Acid → HCID 178478538, compound

HRID 419709Notes

Reaction equation

HRID 419709 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.ClCCl.Cl>>[ClH:25].[Cl:25][C:21]1[CH:20]=[C:19]([C:17]2[N:18]=[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[NH:15][CH:16]=2)[CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 178451791HCID 178451791, compound

Product 1

HCID 178478538HCID 178478538, compound

Procedure

Dissolve 4-[4-(3-Chloro-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (171 mg; 472.54 μmoles) in dichloromethane (3 mL; 46.80 mmoles) and slowly add hydrogen chloride (4 mL; 16.00 mmoles) (4M HCl in dioxane) at room temperature. Stir the solution 1 h. Concentrate in vacuo (2×DCM) to give 4-[4-(3-Chloro-phenyl)-1H-imidazol-2-yl]-piperidine hydrochloride salt.

Workup

  1. concentrationConcentrate in vacuo (2×DCM)

Sources & evidence

ORD record
ord-feba5cefb4ac420d9937a737e2c89f74
Source dataset
uspto-grants-2012_01
Patent number
US08093383B2

Reaction notes

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