Ethanol → HCID 178505529, compound

HRID 419713Notes

Reaction equation

HRID 419713 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.CCO>[OH-].[OH-].[Pd+2]>[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:18]=[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[NH:15][CH:16]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 178505531HCID 178505531, compound

Product 1

HCID 178505529HCID 178505529, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideSolvent

Procedure

Hydrogenate 1-Benzyl-4-[4-(4-fluoro-phenyl)-1H-imidazol-2-yl]-piperidine in 20% Pd(OH)2/C (Pearlman's catalyst) (0.15 gm) in 125 mL 2B EtOH, at 30° C. for 23 h at 60 PSI. Filter and concentrate to yield the title compound as an oil.

Workup

  1. filtrationFilter
  2. concentrationconcentrate

Sources & evidence

ORD record
ord-77face608f2845b6a322124d17bd8095
Source dataset
uspto-grants-2012_01
Patent number
US08093383B2

Reaction notes

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