反应详情

温度

80 °C

Add 4-(4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidine (200 mg, 0.642 mmol), 6-chloropurine (105 mg, 0.679 mmol), and triethylamine (95 μL, 0.681 mmol) to 2-propanol (5 mL). Heat the mixture at 80° C. for 3 h. Cool the mixture to room temperature and concentrate in vacuo. Triturate the solid in CH2Cl2 (10 mL). Purify the remaining solid by silica gel chromatography (60 g, eluting with 40% methanol/methylene chloride, 0.500 L) to provide 6-(4-(4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-7H-purine (179 mg, 65%).

1. temperatureCool the mixture to room temperature
2. concentrationconcentrate in vacuo
3. customTriturate the solid in CH2Cl2 (10 mL)
4. customPurify the remaining solid
5. washby silica gel chromatography (60 g, eluting with 40% methanol/methylene chloride, 0.500 L)