Hydrochloric Acid → methyl 1H-tetrazol-1-ylacetate

HRID 419839Notes

Reaction equation

HRID 419839 reaction equation
[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH:5]=[N:4][N:3]=[N:2]1.Cl.O1CCOC[CH2:12]1>CO>[N:1]1([CH2:6][C:7]([O:9][CH3:12])=[O:8])[CH:5]=[N:4][N:3]=[N:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 5432071-Tetrazolylacetic acid

Product 1

HCID 3153776methyl 1H-tetrazol-1-ylacetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of tetrazol-1-yl acetic acid (5 g, 39 mmol) and 4M hydrochloric acid in dioxan (100 μL) in methanol (50 mL) was heated under reflux for 18 hours. The cooled mixture was evaporated under reduced pressure to provide the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customThe cooled mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1f14cc65617e4ae1985a9137fda2cfc7
Source dataset
uspto-grants-2012_01
Patent number
US08093400B2

Reaction notes

Loading…