反应详情

温度

90 °C

To a solution of 2-(benzyloxy)-5-nitro-3-phenylpyridine (0.98 mmol, 0.3 g) in 10 mL of ethanol, 0.1 mL of HCl 35% and 0.27 g of Fe was added. The mixture was heated at 90° C. for 4 hours. The crude was filtered through Celite and washed with ethanol. The solvent was evaporated, ethyl acetate was added and was washed with NaHCO3 4% aqueous solution, water and brine. The crude was purified by chromatography eluting with DCM/MeOH mixtures affording 0.22 g (yield 79%) of expected product.

1. filtrationThe crude was filtered through Celite
2. washwashed with ethanol
3. customThe solvent was evaporated
4. additionethyl acetate was added
5. washwas washed with NaHCO3 4% aqueous solution, water and brine
6. customThe crude was purified by chromatography
7. washeluting with DCM/MeOH