反应详情

温度

60 °C

A mixture of 2-(2,6-dimethyl piperazine-1-yl)-6-trifluoromethyl benzothiazole (360 mg), (2-bromoethoxy)-t-butyldimethyl silane (257 uL), potassium carbonate (157 mg) and dimethylformamide (2 mL) was stirred at 60° C. for 20 hours. To the reaction solution was added water and extracted with ethyl acetate. The organic layer was washed with water and dried over sodium carbonate. After evaporating the solvent, the residue was purified by column chromatograph on silica gel to give the title compound (265 mg). Yield: 65%.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over sodium carbonate
4. customAfter evaporating the solvent
5. customthe residue was purified by column chromatograph on silica gel