反应详情

A mixture of 2-(2,6-dimethyl piperazine-1-yl)-6-trifluoromethyl benzothiazole (163 mg), (3-bromomethylphenyl)acetic acid methyl ester (126 mg), potassium carbonate (75 mg) and dimethylformamide (4 mL) was stirred at room temperature for 18 hours. To the reaction solution was added water and extracted with ethyl acetate. The organic layer was washed with water and dried over sodium sulphate. The solvent was evaporated under reduced pressure and the residue was purified by column chromatograph on silica gel to give the title compound (171 mg). Yield: 65%.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over sodium sulphate
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by column chromatograph on silica gel