Trifluoroacetic acid → HCID 66657906, compound

HRID 420603Notes

Reaction equation

HRID 420603 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[N:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:16][C:17]([F:22])([F:21])[C:18]([OH:20])=[O:19]>>[F:16][C:17]([F:22])([F:21])[C:18]([OH:20])=[O:19].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]#[N:15])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 1514443Tert-butyl 4-cyanopiperidine-1-carboxylate

Product 1

HCID 66657906HCID 66657906, compoundYield 99%

Procedure

4-Cyanopiperidine-1-carboxylic acid t-butyl ester (5.35 g) was added to trifluoroacetic acid (20 mL) and the mixture was stirred at room temperature for 10 minutes. Trifluoroacetic acid was evaporated under reduced pressure to give the title compound as colorless crystal (5.62 g). Yield: 99%.

Workup

  1. customTrifluoroacetic acid was evaporated under reduced pressure

Sources & evidence

ORD record
ord-03aefceb38424f8a853e89004b7efc01
Source dataset
uspto-grants-2012_01
Patent number
US08097610B2

Reaction notes

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