HCID 67394387, compound → HCID 66766326, compound

HRID 42068Notes

Reaction equation

HRID 42068 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:16]=2[C:17]([O:19]C(C)(C)C)=[O:18])=[CH:10][N:9]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:16]=2[C:17]([OH:19])=[O:18])=[CH:10][N:9]=1

Participants

3

Reactant 1

HCID 67394387HCID 67394387, compound

Product 1

HCID 66766326HCID 66766326, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The solid residue obtained in step A was dissolved in 3 ml of trifluoroacetic acid and stirred for 1 hour at room temperature. The solvent was evaporated and the solid residue was triturated with an isopropyl ether/hexane mixture. The solid was filtered off affording 0.16 g (yield 62%) of the expected product.

Workup

  1. customThe solvent was evaporated
  2. customthe solid residue was triturated with an isopropyl ether/hexane mixture
  3. filtrationThe solid was filtered off

Sources & evidence

ORD record
ord-9024398e87ca43078c2ab2325cb941aa
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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