HCID 67394347, compound → 2-((5,6-Difluoropyridin-3-yl)amino)-5-methylbenzoic acid

HRID 42069Notes

Reaction equation

HRID 42069 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:11]=2[C:12]([O:14]C(C)(C)C)=[O:13])[CH:5]=[N:6][C:7]=1[F:8]>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:11]=2[C:12]([OH:14])=[O:13])[CH:5]=[N:6][C:7]=1[F:8]

Participants

3

Reactant 1

HCID 67394347HCID 67394347, compound

Product 1

HCID 468475152-((5,6-Difluoropyridin-3-yl)amino)-5-methylbenzoic acidYield 15%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The solid residue obtained in step A was dissolved in 0.78 ml of trifluoroacetic acid and stirred for 1 hour at room temperature. The solvent was evaporated and the solid residue was triturated with an isopropyl ether/hexane mixture. The solid was filtered off affording 0.01 g (yield 15%) of the expected product.

Workup

  1. customThe solvent was evaporated
  2. customthe solid residue was triturated with an isopropyl ether/hexane mixture
  3. filtrationThe solid was filtered off

Sources & evidence

ORD record
ord-5a43acfad05a4d7181afe9d1c0bd7baa
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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