HCID 46847798, compound → 2-(6-(3-Cyclopropoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid

HRID 42072Notes

Reaction equation

HRID 42072 reaction equation
[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:11]3[N:16]=[CH:15][C:14]([NH:17][C:18]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:19]=4[C:20]([O:22]C(C)(C)C)=[O:21])=[CH:13][C:12]=3[CH3:32])[CH:8]=[CH:9][CH:10]=2)[CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:11]3[N:16]=[CH:15][C:14]([NH:17][C:18]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:19]=4[C:20]([OH:22])=[O:21])=[CH:13][C:12]=3[CH3:32])[CH:8]=[CH:9][CH:10]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 46847798HCID 46847798, compound

Product 1

HCID 468477972-(6-(3-Cyclopropoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acidYield 74%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The solid residue obtained in step A was dissolved in 1.5 ml of trifluoroacetic acid and stirred for 45 minutes at room temperature. The solvent was evaporated and the solid residue was tritured with a diethyl ether/hexane mixture. The solid was filtered off affording 0.093 g (yield 74%) of the expected product.

Workup

  1. customThe solvent was evaporated
  2. filtrationThe solid was filtered off

Sources & evidence

ORD record
ord-cd5d4032ec684a0fa651815938f396a6
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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