Trifluoroacetic acid → 3,4-Dichlorophenethylamine

Temperature

10 °C

To a stirred suspension of sodium borohydride (10.17 g, 0.2688 mol) in anhydrous tetrahydrofuran (160 ml) under N2 at 0° C. was added a solution of trifluoroacetic acid (30.65 g, 20.71 ml, 0.2688 mol) in anhydrous tetrahydrofuran (25 ml) dropwise over 30 minutes. The mixture was stirred at 10° C. for 10 minutes. A solution of 2-(3,4-dichlorophenyl)acetonitrile (50 g, 0.268 mol) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 30 minutes. The mixture was stirred at room temperature for 1 hour and then poured slowly onto 500 g of crushed ice. The mixture was extracted three times with dichloromethane (300 ml). The organic phases were combined, washed three times with aqueous saturated NaHCO3 (250 ml) and once with water (250 ml), dried over sodium sulfate and concentrated under reduced pressure to provide a yellow oil as the crude product (56 g). This crude product was dissolved in dichloromethane (560 ml, 10 ml/g) and extracted three times with 2 M HCl solution (300 ml). The combined aqueous layers were washed with dichloromethane (300 ml), basified to pH 10 by addition of 1 M NaOH at 0° C. then extracted three times with dichloromethane (500 ml). The combined organic phases containing the product were dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide the desired 2-(3,4-dichlorophenyl)ethylamine free base as a light yellow oil (32.07 g, 62% yield).

1. stirringThe mixture was stirred at room temperature for 1 hour
2. extractionThe mixture was extracted three times with dichloromethane (300 ml)
3. washwashed three times with aqueous saturated NaHCO3 (250 ml)
4. dry with materialonce with water (250 ml), dried over sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customto provide a yellow oil as the crude product (56 g)
7. extractionextracted three times with 2 M HCl solution (300 ml)
8. washThe combined aqueous layers were washed with dichloromethane (300 ml)
9. additionbasified to pH 10 by addition of 1 M NaOH at 0° C.
10. extractionthen extracted three times with dichloromethane (500 ml)
11. additionThe combined organic phases containing the product
12. dry with materialwere dried over sodium sulfate
13. filtrationfiltered
14. concentrationconcentrated under reduced pressure

ORD record

ord-f0018355734043319ff30cc99e803202

Source dataset

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08097636B2