反应详情

温度

10 °C

Dissolve 16.2 g (0.0889 mol) of 3,4-dimethoxy-6-hydroxybenzaldehyde in 80 ml of DMF. Cool to 10° C. and add in portions 24.6 g (0.178 mol) of potassium carbonate. Allow to return to ambient temperature and stir for 30 minutes. Cool to approximately 10° C. and pour in dropwise 10.1 ml (0.093 mol) of N,N-dimethylsulphamoyl chloride. Allow to return to ambient temperature and stir for 2 h. Pour the reaction mixture into 600 g of water and ice and stir for 1 h at ambient temperature. The precipitate formed is filtered off and washed 3 times with 50 ml of water each time and then dried in vacuo. 21.3 g of title product are obtained.

1. customto return to ambient temperature
2. temperatureCool to approximately 10° C.
3. customto return to ambient temperature
4. stirringstir for 2 h
5. stirringstir for 1 h at ambient temperature
6. customThe precipitate formed
7. filtrationis filtered off
8. washwashed 3 times with 50 ml of water each time
9. customdried in vacuo