Triphenylphosphine → HCID 57976185, compound

HRID 420892Notes

Reaction equation

HRID 420892 reaction equation
[N:1]([CH2:4][C:5]1([CH3:23])[NH:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[C:6]1=[O:22])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C1COCC1.O>[NH2:1][CH2:4][C:5]1([CH3:23])[NH:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[C:6]1=[O:22]

Participants

5

Reactant 2

HCID 11776TriphenylphosphineHCID 57976173HCID 57976173, compound

Product 1

HCID 57976185HCID 57976185, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

5-Azidomethyl-3-(4-chloro-3-trifluoromethyl-phenyl)-5-methyl-imidazolidine-2,4-dione (500 mg, 1.45 mmoL), Ph3P (380 mg, 1.45 mmoL) in THF (5 mL) and water (1 mL) was heated to reflux for 4 hrs. The solid was filtered through a pad of Celite. The Celite was washed with ethyl acetate. The combined filtrate was concentrated to give a colorless oil, which was used without further purification.

Workup

  1. temperatureto reflux for 4 hrs
  2. filtrationThe solid was filtered through a pad of Celite
  3. washThe Celite was washed with ethyl acetate
  4. concentrationThe combined filtrate was concentrated
  5. customto give a colorless oil, which
  6. customwas used without further purification

Sources & evidence

ORD record
ord-6485334b3bf540e3b9139c6547eb8c6b
Source dataset
uspto-grants-2012_01
Patent number
US08097730B2

Reaction notes

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