HRID420995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)CN(C)Cc1c(C(=O)O)n(-c2ccc(OC(C)C)cc2)c2ccc(-c3ccc(C(C)(C)C)cc3)cc12

HCID66657582

未命名化合物

PRODUCTS

生成物

结构：CC(C)Oc1ccc(-n2c(C(=O)O)c(C[NH+](C)CC(=O)O)c3cc(-c4ccc(C(C)(C)C)cc4)ccc32)cc1.[Cl-]

HCID86628823

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

An excess of HCl (4 M in dioxane) was added to a suspension of 5-(4-tert-butylphenyl)-3-[(ethoxycarbonylmethylmethyl-amino)methyl]-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester (189 mg, 0.35 mmol; see step (e) above) in dioxane (4 mL). After 10 min the mixture was concentrated and the residue treated with Et2O and filtered to give the title compound.

WORKUP

后处理

concentrationAfter 10 min the mixture was concentrated
additionthe residue treated with Et2O
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-49a4a5ba15e3490fb1da1f98aefc2d46
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08097623B2
来源说明: uspto-grants-2012_01

反应 SMILES

[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH:28]([CH3:30])[CH3:29])=[CH:23][CH:22]=2)[C:16]([C:31]([OH:33])=[O:32])=[C:15]3[CH2:34][N:35]([CH2:37][C:38]([O:40]CC)=[O:39])[CH3:36])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3]>O1CCOCC1>[Cl-:1].[C:2]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH:28]([CH3:30])[CH3:29])=[CH:23][CH:22]=2)[C:16]([C:31]([OH:33])=[O:32])=[C:15]3[CH2:34][NH+:35]([CH2:37][C:38]([OH:40])=[O:39])[CH3:36])=[CH:10][CH:11]=1)([CH3:4])([CH3:5])[CH3:3]