Hydrochloric Acid → HCID 11406715, compound

HRID 421072Notes

Reaction equation

HRID 421072 reaction equation
C[O:2][C:3](=[O:28])[C:4]1[CH:26]=[CH:25][C:24]([OH:27])=[C:6]([C:7]([NH:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=2)=[O:8])[CH:5]=1.CO.[OH-].[Na+].Cl>O1CCCC1>[F:17][C:16]([F:18])([F:19])[C:14]1[CH:15]=[C:10]([NH:9][C:7](=[O:8])[C:6]2[CH:5]=[C:4]([CH:26]=[CH:25][C:24]=2[OH:27])[C:3]([OH:28])=[O:2])[CH:11]=[C:12]([C:20]([F:23])([F:21])[F:22])[CH:13]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 11327249N-[3,5-Bis(trifluoromethyl)phenyl]-4-hydroxyisophthalamic acid methyl ester

Product 1

HCID 11406715HCID 11406715, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-[3,5-Bis(trifluoromethyl)phenyl]-4-hydroxyisophthalamic acid methyl ester (2.85 g, 7 mmol) was suspended in a mixed solvent of methanol (14 mL) and tetrahydrofuran (14 mL). 2 N aqueous sodium hydroxide (14 mL) was added, and the mixture was refluxed for 2 hours. After cooling, the reaction mixture was added 2 N hydrochloric acid (20 ml) and the separated solid was filtered, washed with water, dried to give the title compound (2.68 g, 97.4%) as a white crystal.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe separated solid was filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-5b7105d3d88c4f3c9f8fa779441eabd8
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

Loading…