反应详情

A mixture of 2-amino-5-bromo-4-[(1,1-dimethyl)ethyl]thiazole (0.10 g, 0.42 mmol), piperidine (0.1 mL), potassium carbonate (0.20 g) and acetonitrile (4 mL) was refluxed for 3 hours. The reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=2:1) to give the title compound (80.7 mg, 79.3%) as a yellow crystal.

1. temperaturewas refluxed for 3 hours
2. extractionextracted with ethyl acetate
3. washAfter the organic layer was washed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. customthe residue obtained by evaporation under reduced pressure
6. customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=2:1)