Trifluoroacetic acid → HCID 16731193, compound

HRID 421703Notes

Reaction equation

HRID 421703 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH:10]=2)=[O:7])=[CH:4][N:3]=1.C([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:6](=[O:7])[C:5]2[CH:26]=[CH:27][C:2]([N:35]3[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]3)=[N:3][CH:4]=2)=[CH:10][C:11]=1[NH:16][C:17](=[O:25])[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 16731033HCID 16731033, compound

Product 1

HCID 16731193HCID 16731193, compound

Procedure

6-chloro-N-(4-chloro-3-(4-fluorobenzamido)phenyl)nicotinamide (0.17 mmol) was used in general procedure 3 with Boc-piperazine (0.868 mmol). The product was deprotected by treatment with TFA and purified by RP-HPLC to give N-(4-chloro-3-(4-fluorobenzamido)phenyl)-6-(piperazin-1-yl)nicotinamide. MS (Q1) 554.0 (M)+

Workup

  1. custompurified by RP-HPLC

Sources & evidence

ORD record
ord-eb2b610aa65c452497238959e8805b6d
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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