反应详情

To a solution of 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester (1.00 equivalent) in DMF is added NBS (1.20 equivalents) at room temperature. After stirring for 16 hours at room temperature, the reaction mixture is diluted with EtOAc and washed with water. The organic layer is dried over MgSO4, filtered, and concentrated in vacuo to give the crude material that is purified by trituration or flash column chromatography to afford the desired product as necessary.

1. washwashed with water
2. dry with materialThe organic layer is dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customto give the crude material that
6. customis purified by trituration or flash column chromatography