反应详情

Cs2CO3 (0.51 eq) was added to a solution of 4-(aminosulfonyl)butanoic acid (1 M) in DMF. After 1 h, benzyl bromide (1 eq) was introduced and the reaction left to stir overnight before diluting with DCM and filtering. The filtered liquor was concentrated in vacuo, the residue taken up in DCM and washed with saturated aqueous NaHCO3, water and brine, before being dried over Na2SO4, filtered and concentrated in vacuo. Trituration of the residue with Et2O afforded the title compound as a white solid (27%). (ES+) m/z 280 (M+Na)+

1. waitthe reaction left
2. filtrationfiltering
3. concentrationThe filtered liquor was concentrated in vacuo
4. washwashed with saturated aqueous NaHCO3, water and brine
5. dry with materialbefore being dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo