反应详情

Dimethyl 13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-6,10-dicarboxylate was dissolved in THF:MeOH (1:1) (0.02 M) and to that solution 1.4 eq. of an aq. solution of lithium hydroxide monohydrate (0.1 N) were added. The solution was stirred at RT for 2 h. Volatiles were reduced in vacuo, the residue acidified with 1N HCl (aq) and the resultant precipitate filtered and dried in vacuo to afford the title compound (99%). (ES+) m/z 420 (M+H)+.

1. additionwere added
2. filtrationthe resultant precipitate filtered
3. customdried in vacuo