反应详情

温度

0 °C

2-[4-(4-Benzyl-phthalazin-1-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-5′-yl]-propane-1,2-diol (100 mg, 0.219 mmol) is combined with THF (1.5 mL). The reaction is chilled to 0° C. and triethylamine (95 μL, 0.329 mmol) is added followed by mesyl chloride (100 μL, 0.2 M in THF, 0.263 mmol). The reaction is allowed to warm to room temperature and stir for 96 h. Reaction is quenched with saturated ammonium chloride solution (0.5 mL), diluted with additional water and extracted with EtOAc. Wash combined organics with brine. Concentrate organics in vacuo to afford the title compound (117 mg, 99%).

1. temperatureto warm to room temperature
2. customReaction
3. customis quenched with saturated ammonium chloride solution (0.5 mL)
4. additiondiluted with additional water
5. extractionextracted with EtOAc
6. washWash