2-[2-Nitro-3-(3-nitro-phenylamino)-phenyl]-malonic acid dimethyl ester → [2-Nitro-3-(3-nitro-phenylamino)-phenyl]-acetic acid

HRID 422017Notes

Reaction equation

HRID 422017 reaction equation
C[O:2][C:3](=[O:28])[CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[C:10]=1[N+:25]([O-:27])=[O:26])C(OC)=O>Cl>[N+:25]([C:10]1[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:4][C:3]([OH:28])=[O:2])([O-:27])=[O:26]

Participants

3

Reactant 1

HCID 866231752-[2-Nitro-3-(3-nitro-phenylamino)-phenyl]-malonic acid dimethyl ester

Product 1

HCID 59804360[2-Nitro-3-(3-nitro-phenylamino)-phenyl]-acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-[2-Nitro-3-(3-nitro-phenylamino)-phenyl]-malonic acid dimethyl ester (1.26 g, 3.24 mmol) is heated in 6 N hydrochloric acid (100 ml) at 110° C. for 10 hours. It is then cooled to room temperature; the precipitate therefore formed is collected by vacuum filtration to give the desired compound: LC-MS: 318.0 (MH+).

Workup

  1. customthe precipitate therefore formed
  2. filtrationis collected by vacuum filtration

Sources & evidence

ORD record
ord-11aaf3d44d0c4f219057899e34b9660f
Source dataset
uspto-grants-2012_01
Patent number
US08101608B2

Reaction notes

Loading…