反应详情

温度

70 °C

To a solution of 2-(4-chlorophenyl)-5-(1-(2,2-dimethoxyethyl)-1H-indazol-5-yl)furo[3,2-c]pyridine-4-one (1.66 g, 3.69 mmol) in THF (36 mL) at 40° C. was added HCl in H2O (36 mL, 2.0 M). The solution was heated to 70° C. for 3 h then to 80° C. for 2 h. The reaction mixture was diluted with H2O (75 mL) and CH2Cl2 (75 mL). The resulting solids were collected by filtration and dried to yield the title compound (1.00 g, 64%) as a light brown solid. ESI MS m/z 422 [M+H]+.

1. filtrationThe resulting solids were collected by filtration
2. customdried