反应详情

温度

100 °C

A mixture consisting of 2-phenylpyrimidine-5-carbonitrile (200 mg, 1.10 mmol), sodium azide (80 mg, 1.2 mmol) and ammonium chloride (66 mg, 1.2 mmol) in DMF (3 mL) was stirred at 100° C. for 24 hours. The reaction mixture was allowed to cool to room temperature. Upon addition of 1N hydrochloric acid (3 mL), a white solid precipitated. The precipitate was isolated by filtration and recrystallized from ethanol to afford the title compound as a white solid (123 mg, 50% yield); melting point 237° C.; 1H-NMR (400 MHz; DMSO-d6) δ 9.51 (s, 2H), 8.51-8.53 (m, 2H), 7.61-7.65 (m, 3H); LC/MS (ESI+) m/z 225; H-PGDS FPBA IC50: 2.5 μM.

1. temperatureto cool to room temperature
2. customa white solid precipitated
3. customThe precipitate was isolated by filtration
4. customrecrystallized from ethanol