反应详情

4-Dimethylaminopyridine (30 mg), phenol (23 mg), and 3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}propionic acid (100 mg) were dissolved in acetone (1 mL). After addition of WSC hydrochloride (50 mg), the mixture was stirred at room temperature for 1 day. The reaction mixture was concentrated, and purified by column chromatography on silica gel (ethyl acetate:hexane=1:1, v/v) to give the title compound (Compound 1-1) (0.088 g) as a colorless solid.

1. concentrationThe reaction mixture was concentrated
2. custompurified by column chromatography on silica gel (ethyl acetate