反应详情

温度

0 °C

To an ice cooled solution of tert-butylamine (12.55 ml) in THF (60 ml) was added a solution of 2-fluoro-4-methylbenzene-1-sulfonyl chloride (5 g) in THF (25 ml), dropwise. After stirring for 15 min at 0° C., the reaction mixture was allowed to warm and stirred at room temperature for 2 hours. The HCl salt was removed by filtration and the filtrate was concentrated to give a yellow residue, which was triturated with Et2O and Hexanes to give 5.10 g N-tert-butyl-2-fluoro-4-methylbenzenesulfonamide as an off-white granular solid.

1. temperatureto warm
2. stirringstirred at room temperature for 2 hours
3. customThe HCl salt was removed by filtration
4. concentrationthe filtrate was concentrated
5. customto give a yellow residue, which
6. customwas triturated with Et2O and Hexanes