(2S)-2-[(1,1-Dimethylethoxy)methyl]oxirane → HCID 66676935, compound

HRID 423446Notes

Reaction equation

HRID 423446 reaction equation
C([O:5][C:6](=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18])C(C)C.C[C:21]([CH3:24])([O-:23])[CH3:22].[Li+].C([O:30]C[C@@H]1CO1)(C)(C)C>CN(C)C=O>[CH3:18][O:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[O:10][CH2:9][CH2:8][N:7]1[CH2:22][C@@H:21]([CH2:24][OH:30])[O:23][C:6]1=[O:5]

Participants

5

Reactant 3

HCID 11768605(2S)-2-[(1,1-Dimethylethoxy)methyl]oxiraneHCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)HCID 131729414HCID 131729414, compound

Product 1

HCID 66676935HCID 66676935, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using N,N-dimethylformamide solution of isobutyl-2-(2-methoxyphenoxy)ethylcarbamate 26.7 g (0.1 mol), lithium-t-butoxide 1.60 g (0.02 mol) and (S)-2-t-butoxymethyl-oxiran 14.3 g (0.11 mol), the procedures as described in Example 1 were carried out to obtain the targeted product.

Workup

  1. customto obtain the targeted product

Sources & evidence

ORD record
ord-58c57d3cdd4c43489cc87d9d16042802
Source dataset
uspto-grants-2012_01
Patent number
US08101781B2

Reaction notes

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