2-Propanol, 2-methyl-, lithium salt (1:1) → HCID 86632376, compound

HRID 423448Notes

Reaction equation

HRID 423448 reaction equation
[CH2:1]([O:3][C:4](=[S:17])[NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16])[CH3:2].C[C:19](C)([O-:21])C.[Li+]>CN(C)C=O>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][N:5]1[CH2:2][C@@H:1]([CH2:19][OH:21])[O:3][C:4]1=[S:17]

Participants

4

Reactant 2

HCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)HCID 131729415HCID 131729415, compound

Product 1

HCID 86632376HCID 86632376, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using N,N-dimethylformamide solution of ethyl-2-(2-methoxyphenoxy)ethylthiocarbamate 25.5 g (0.1 mol) [J. Chem. Soc., 1952, 2076; J. Chem. Soc., 1952, 2079; Tetrahedron Lett., 1969, 3631], lithium-t-butoxide 1.6 g (0.02 mol) and (S)-2-oxyranylmethoxy-tetrahydropyran 17.38 g (0.11 mol), the procedures as described in Example 1 were carried out to obtain the targeted product.

Workup

  1. customto obtain the targeted product

Sources & evidence

ORD record
ord-36273f88508e4ece81fb8aded76c47a2
Source dataset
uspto-grants-2012_01
Patent number
US08101781B2

Reaction notes

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