Triethylamine → HCID 86632380, compound

HRID 423450Notes

Reaction equation

HRID 423450 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][CH:17]=[CH:16][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:12][C@H:11]([CH2:13][OH:14])[O:10][C:9]1=[O:15].C(N(CC)CC)C.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>ClCCl>[CH3:27][S:28]([O:14][CH2:13][C@@H:11]1[O:10][C:9](=[O:15])[N:8]([CH2:7][CH2:6][O:5][C:4]2[CH:16]=[CH:17][CH:18]=[CH:19][C:3]=2[O:2][CH3:1])[CH2:12]1)(=[O:30])=[O:29]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66677026HCID 66677026, compound

Product 1

HCID 86632380HCID 86632380, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using dichloromethane solution of the compound of formula 2 prepared in Example 2 80.1 g (0.3 mol), triethylamine 45.5 g (0.45 mol) and methanesulfonyl chloride 37.8 g (0.33 mol), the procedures as described in Example 7 were carried out to obtain the targeted product.

Workup

  1. customto obtain the targeted product

Sources & evidence

ORD record
ord-4f42f6dbe522482ea57325f2ab3d6d49
Source dataset
uspto-grants-2012_01
Patent number
US08101781B2

Reaction notes

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