反应详情

To a suspension of 2,4-dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (1.3 g) in THF was added 1N NaOH (6.6 ml). The reaction mixture was stirred at room temperature for 30 min. Then another 2.2 ml 1N NaOH was added. After 2 hours, the reaction mixture was neutralized by adding 2N HCl and extracted with EtOAc. The organic layer was dried and concentrated until solid was formed. The solid was collected by filtration, washed with acetonitrile to give 0.97 g 2-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ol.

1. waitAfter 2 hours
2. extractionextracted with EtOAc
3. customThe organic layer was dried
4. concentrationconcentrated until solid
5. customwas formed
6. filtrationThe solid was collected by filtration
7. washwashed with acetonitrile