反应详情

温度

-10 °C

To a −25° C. cooled solution of (2S)-2-methylbutan-1-ol (8.8 g) and triethylamine (30 ml) in THF (50 ml), a solution of methanesulfonyl chloride (1.14 g) in THF (10 ml) was drop wise added. After complete addition (15 min) the reaction mixture was further stirred for 2 h at −10° C. then for 30 min at 0° C. It was then filtered over celite and evaporated to dryness to give nearly pure (2S)-2-methylbutyl methanesulfonate as yellowish oil.

1. additionwise added
2. additionAfter complete addition (15 min) the reaction mixture
3. waitfor 30 min at 0° C
4. filtrationIt was then filtered over celite
5. customevaporated to dryness