反应详情

3,4-dimethoxybenzaldehyde (Veratraldehyde) (9.13 g, 55 mM) was heated with malonic acid diethyl ester (8.00 g, 50 mM), acetic acid (0.29 ml) and piperidine (0.74 ml) in benzene (100 ml) in an apparatus equipped with a water separator (Dean-Stark tube) until 50 mM water was separated. After washing the benzene solution with water, it was dried over anhydrous magnesium sulfate. After drying, benzene was evaporated under reduced pressure to obtain a crude product (15.40 g). The crude product thus obtained is pure enough, and can be used in the subsequent reaction without further purification.

1. customwas separated
2. washAfter washing the benzene solution with water, it
3. dry with materialwas dried over anhydrous magnesium sulfate
4. customAfter drying
5. custombenzene was evaporated under reduced pressure
6. customto obtain a crude product (15.40 g)